You look lovely today, have you had a wash?

12th Doctor / The Caretaker / Doctor Who

 Don't listen to him. It's just the ravings of a demented space tramp.

The Doctor / The Creature from the Pit  / Doctor Who

You know, you're the classic example of the inverse ratio between the size of the mouth and the size of the brain.

The Doctor / The Robots of Death / Doctor Who

 You're mister thick, thick, thickety thick-face from Thicktown, Thickania... and so's your dad!

10th Doctor / The Girl in the Fireplace / Doctor Who

 I think... no, I am positive that you are the most unattractive man I have ever met in my entire life. In the short time we've been together, you have demonstrated every loathsome characteristic of the male personality and even discovered a few new ones.  You are physically repulsive, intellectually retarded, you're morally reprehensible, vulgar, insensitive, selfish, stupid, you have no taste, a lousy sense of humor and you smell.  You're not even interesting enough to make me sick.

Alexandra Medford / The Witches of Eastwick

 Well, I'll tell you something that should be of vital interest to you.  That you, sir, are a NITWIT!

The Doctor / Doctor Who

 You bowl like your momma. Unless, of course, she bowls well, in which case you bowl nothing like her.

Sheldon Cooper / The Wheaton Recurrence / The Big Bang Theory